The current RNA based SARS-CoV-2 vaccines were approved in the US using an emergency order without extensive long term safety testing. In this paper the Pfizer COVID-19 vaccine was evaluated for the potential to induce prion-based disease in vaccine recipients. The Pfizer-BioNTech COVID-19 vaccine uses new messenger RNA (mRNA) technology, which contains brief genetic instructions for human cells to temporarily manufacture proteins that mimic a small part. . People didn't have these diseases before the shot and suddenly they develop them after the shot. It may be hypothesized that immunosuppressive agents prescribed to these patients mitigate or even prevent side effects related to vaccine . Predictably, the twist is the claim that the mRNA in vaccines is what causes prion disease and results in Alzheimer's disease. Antivax immunologist J. Bart Classen published a paper claiming that mRNA-based COVID-19 vaccines can cause prion disease leading to neurodegenerative diseases like Alzheimer's dementia. 2. A Possible Link to Prion Diseases and Neurodegeneration. "People didn't have these diseases before the shot and suddenly they develop them after the shot. They are not real vaccines. Classen's claim that mRNA vaccines can cause prion disease leading to neurodegenerative disorders like Alzheimer's disease is just another example of this. Many have argued that SARS-CoV-2 spike protein and its mRNA . The latest myth is that mRNA vaccines may trigger prion diseases like Alzheimer's. Credit: Public Domain/Wikipedia With Classen's claim, I'm hard pressed to think of an old antivaccine trope that hasn't yet been weaponized against COVID-19 vaccines, with one exception. Therefore, it is not necessary to vaccinate the entire population to trigger a genocide. Since the mRNA in the vaccines has been modified to spew out very high amounts of spike protein (far greater than that of the actual virus), the risk of excessive buildup in the cytoplasm is high. Prion diseases are incurable and always fatal. Ingraham cites Seneff's paper, titled, "Worse Than the Disease? Normal RNA uses a uricil nucleotide as part of its coding, but our immune systems recognize uricil . They are caused by an infectious agent known as a prion, which is derived from a misfolded version of a normal host protein known as prion protein. Prion diseases can affect both humans and animals and are sometimes spread to humans by infected meat products. The most common form of prion disease that affects humans is Creutzfeldt-Jakob disease (CJD). Prion diseases are associated with the prion protein, which is found in many body tissues, including the brain. . She noted that most of . we'll see a dramatic spike in prion diseases, autoimmune diseases, neurodegenerative diseases at . Therefore, prions are unlikely to be propagated in the cells used to grow vaccine viruses. A prion vaccine could be extremely useful in at-risk populations or individuals; however, the rate of prion disease in humans is not large enough to justify vaccination in whole populations. There are no known ways to cure prion diseases but RML scientists are working to develop treatments. Linial said she believes that the reason no mRNA vaccine has been developed yet is because there was just no need to move this fast on a vaccine until COVID-19 came along. Do COVID-19 RNA-based vaccines put at risk of immune-mediated diseases? . 731. Developments, such as an increase in auto-immune and neurodegenerative diseases, which may take 10 to 15 years before manifesting themselves." "We are in for a big surprise down the road," she predicts. Neither Pfizer nor Moderna, both of which manufacture mRNA-based . Two GGΨA sequences were found. Authors [18] found prion related sequences in the COVID-19 spike protein which were not found in related coronaviruses. Such a . (CJD), a prion disease (or protein misfolding disease) comparable to mad cow disease" as well as Alzheimer disease, "which people are getting at an increasingly younger age." She argued that the "recklessly and haphazardly . The same eventually happens with an mRNA vaccine, but there's a crucially different first step: The mRNA must be taken up by your body cells, and then your own cells produce the protein . Unintended Consequences of mRNA Vaccines Against COVID-19 BY Joseph Mercola TIMEMarch 3, 2022 . The RNA sequence of the vaccine as well as the spike protein target interaction were . Why are mRNA vaccines considered unsafe? SINGAPORE - Claims that mRNA Covid-19 vaccines could cause neurological diseases such as Alzheimer's and Parkinson's have been making the rounds on social media and messaging apps recently. Covid-19 and autoimmunity. an important and highly concerning study published early this year in the journal microbiology & infectious diseases titled, " covid-19 rna based vaccines and the risk of prion diseases ," addresses one of the many potential, unintended, adverse health effects of the experimental mrna covid-19 vaccines presently being deployed worldwide, namely, … Development of new vaccine technology has been plagued with problems in the past. The mRNA COVID-19 vaccines authorized for emergency use in the U.S. demonstrated safety and efficacy in thousands of people during clinical trials. "There is no credible evidence that the Covid-19 vaccines are associated with the development of prion-related disease or neurodegenerative diseases like Alzheimer's or Parkinson's". A typical vaccine directly stimulates the immune response. An mRNA vaccine is a type of vaccine that uses a copy of a molecule called messenger RNA (mRNA) to produce an immune response. At first I didn't understand WHY the mRNA vaccines would increase the risk of prion disease, since they code for the same spike protein as the natural infection. Creutzfeldt-Jakob disease (CJD) is a rapidly progressive, invariably fatal neurodegenerative disorder believed to be caused by an abnormal isoform of a cellular glycoprotein known as the prion protein. "Human prion diseases are conceivably the most heterogeneous neurodegenerative disorders, and a growing body of research indicates that they are caused by distinct strains of human prions," said Jiri Safar, professor of pathology, neurology and neurosciences at Case Western, who led the research. Center for Inquiry - Executive Office. "I have done a lot of research and am . PO Box 741 Amherst, NY 14226 (716) 636-4869. Prion disease. The current RNA based SARSCoV-2 vaccines were approved in the US using an emergency order without extensive long term safety testing. There is no other explanation for this. Ongoing safety monitoring in millions of vaccinated people further shows that mRNA COVID-19 vaccines are safe and don't alter human DNA. PrP . Prions are membrane proteins and when they misfold, they form crystals in the cytoplasm resulting in prion disease. Since the mRNA in the vaccines has been modified to spew out very high amounts of spike protein (far greater than that of the actual virus), the risk of excessive buildup in the cytoplasm is high. By Mark Ellis -. Prion diseases or transmissible spongiform encephalopathies (TSEs) are a family of rare progressive neurodegenerative disorders that affect both humans and animals. No, COVID mRNA Vaccine Won't Cause Alzheimer's or Prion Disease By Alex Berezow, PhD — February 19, 2021 The coronavirus pandemic has spawned an equally concerning mis- and disinformation pandemic. The claim: Moderna executive said coronavirus vaccines alter DNA. The results indicate that the vaccine RNA has specific sequences that may induce TDP-43 and FUS to fold into their pathologic prion confirmations. . Adverse event reaction rates from AstraZeneca's vaccine were compared to… The study concluded by suggesting that public health institutions employ a more cautious approach to rolling out new experimental technologies to the public rather than rush to . They are distinguished by long incubation periods, characteristic spongiform changes associated with neuronal loss, and a failure to induce inflammatory response. How the Vaccines Damage The Body. The RNA sequence of the vaccine as well as the spike protein target interaction were analyzed for the . this paper the Pfizer COVID-19 vaccine was evaluated for the potential to induce prion-based disease in vaccine recipients. Genetic defects simply cannot be removed from the body. that COVID-19 vaccines could potentially induce prion disease. Vaccines could be given to prion researchers, those with a genetic propensity toward the disease, or those individuals suspected of consuming prion . What are prions, and can these vaccines cause prion disease? In reply to "potential antigenic cross-reactivity between SARS-CoV-2 and human tissue with a possible link to an increase in autoimmune diseases" . Infection with this disease leads to death usually within 1 year of onset of illness. The claim originates from a paper (likely not peer-reviewed) published earlier this year that asserts the mRNA component of the vaccine causes prion disease. Classen's claim that mRNA vaccines can cause prion disease leading to neurodegenerative disorders like Alzheimer's disease is just another example of this. The mRNA allows its message to be transcribed throughout the body, uncontrollably. The vaccine slowed the progression of prion disease in the remaining 70% of the experimental mice, allowing them to live longer than control mice, which did not receive the vaccine and died within . There is no doubt the mRNA vaccines are causing prion diseases. The UK's Yellow Card database of COVID-19 vaccine adverse event reports was evaluated for signals consistent with a pending epidemic of COVID vaccine induced prion disease. Center for Inquiry - Headquarters. There is no other explanation for this." "None of the 'fact checkers can explain the cause of the excess rates. With the new mRNA vaccines developed by Pfizer/BioNTech and Moderna likely to be available . Prion diseases, also known as transmissible spongiform encephalopathies or TSEs, are a group of rare, fatal brain diseases that affect animals and humans. The U.S. has reached a major milestone with 50% of adults being fully vaccinated against the coronavirus , but vaccine hesitancy . Prion diseases comprise several conditions. Do COVID-19 RNA-based vaccines put at risk of immune-mediated diseases? Prion diseases are a collection of neurodegenerative diseases that are induced through the misfolding of important bodily proteins, which form toxic oligomers that eventually precipitate out as fibrils causing . A microbe or protein injection sets off alarms, inflammation occurs, and antibodies are produced. No one, to my knowledge . Classen's article did assert that mRNA vaccines could cause prion diseases, as well as other neurological conditions such as Alzheimer's disease, but only cited as evidence of the claim a three-sentence summary of an unspecified analysis of the Pfizer/BioNTech COVID-19 vaccine. In the early 1980s, there was a monstrous scandal in France when more than 120 children died of Creutzfeldt-Jakob disease. Alzheimer's type dementia, multiple sclerosis, neurological symptoms). A prion is a type of protein that can trigger normal proteins in the brain to fold abnormally. The study also produced evidence of vaccine shedding, prion and neurodegenerative diseases, and coronavirus variants brought on by vaccinating a minority of the public. Prion diseases are fatal neurodegenerative disorders caused by misfolding of the normal prion protein into an infectious cellular pathogen. The paper was published in Microbiology and Infectious Diseases, whose publisher, Scivision Publishers, is included in Beall's list of publishers of predatory journals. With Classen's claim, I'm hard pressed to think of an old antivaccine trope that hasn't yet been weaponized against COVID-19 vaccines, with one exception. Study mRNA COVID-19 vaccines inducing prion-based disease causing brain to degenerate progressively.. mRNA vaccine induced prions, may cause neurodegenerative diseases ALS, front temporal lobar . In this paper the Pfizer COVID-19 vaccine was evaluated for the potential to induce prion-based disease in vaccine recipients. The claim originates from a paper (likely not peer-reviewed) published earlier. The claim that COVID-19 vaccines can cause prion and other neurodegenerative diseases is FALSE, based on our research. Through the prion-like action of the spike protein, we will likely see an alarming increase in several major neurodegenerative diseases, including Parkinson's disease, CKD . The CDC notes that "prion diseases are usually rapidly progressive and always fatal." Mad Cow Disease "progressively attacks the brain but can remain dormant for decades," per the BBC. There is no other explanation for this. Although the exact 3D structure of PrP Sc is not known, it has a higher proportion of β-sheet structure in place of the . Immunologist J. Bart Classen, one-time National Institutes of Health (NIH) contract scientist and proprietor of Classen Immunotherapies, a Maryland biotechnology firm, published a paper in February outlining the potential for messenger RNA (mRNA) COVID vaccines to trigger development of prion diseases as well as other chronic diseases.. Prion or "prion-like" diseases include Alzheimer's . RML scientists also are working to adapt the RT-QuIC assay to detect the proteins that cause Alzheimer's disease, Parkinson's disease, dementia with Lewy bodies, and other neurological diseases involving misshapen proteins. . Each disease also has a particular genetic profile of the prion protein gene. >> Anonymous Thu Mar 4 16:22:40 2021 No . The infectious isoform of PrP, known as PrP Sc, or simply the prion, is able to convert normal PrP C proteins into the infectious isoform by changing their conformation, or shape; this, in turn, alters the way the proteins interconnect.PrP Sc always causes prion disease. In reply to "potential antigenic cross-reactivity between SARS-CoV-2 and human tissue with a possible link to an increase in autoimmune diseases" . The investigational vaccine known as mRNA-1273 was 94.1% efficacious in preventing symptomatic coronavirus disease 2019 (COVID-19), according to preliminary results from a Phase 3 clinical trial reported in the New England Journal of Medicine. Dr. Wolfgang Wodarg, a German physician and epidemiologist, said: "In fact, this 'promising vaccine' for the vast majority of people should be FORBIDDEN, because it is genetic . mRNA Vaccines, Spike Proteins, and Antibody-Dependent Enhancement (ADE) . The hope is that the mRNA vaccine will . Many of the potential long-term risks that could result from receiving one of the COVID-19 vaccines are reviewed, including the potential for the spike protein and its mRNA to cause prion disease and reasons why the vaccine could be much more dangerous than the natural infection. Normally, prion protein does not cause disease and resides on the surface of many cell types. Classen, in his paper, argued that the RNA in mRNA vaccines like Pfizer's may induce two specific proteins (TDP-43 and FUS) to "fold into their pathologic prion configurations.". The findings suggest that regulatory approval for COVID vaccines was premature and that widespread use should be halted until full long term safety studies evaluating prion toxicity has been complete, and alternatives like the Measles Mumps Rubella (MMR) vaccine should be explored for those desiring immunization against COVID-19. Fact Check-No evidence that Pfizer's COVID-19 vaccine causes Alzheimer's disease. Mahane E. Covid-19: Vaccine candidate may be more than 90% effective, interim results indicate. A senior research scientist at MIT warned about the potential relationship between the spike protein produced in mRNA vaccines and a wide range of both acute and long-term diseases, such as blood disorders, neurodegenerative diseases, and autoimmune diseases. Expand The mRNA vaccines contain only the code for the SARS-CoV-2 envelope spike protein, whereas the DNA-based vaccines both contain an adenovirus viral vector that has been augmented with DNA that codes for the SARS-CoV-2 spike protein. There is no doubt the mRNA vaccines are causing prion diseases. The fatal prion damage to the brain is transmissible from an infected, vaccinated person to a healthy, unvaccinated person. MIT scientist Stephanie Seneff's paper,1 "Worse Than the Disease: Reviewing Some Possible Unintended Consequences of mRNA Vaccines Against COVID-19," published in the International Journal of Vaccine Theory, Practice and Research in collaboration with Dr. Greg Nigh, is still one of the best . While there is still no evidence indicating that COVID-19 vaccinations can cause prion-related diseases, the VAERS database now reports a very small number of relevant cases (ex. This journal is not included in the National Library of Medicine, the largest index of journals of . Classic CJD is a human prion disease. Prions are membrane proteins and when they misfold, they form crystals in the cytoplasm resulting in prion disease. Though under investigation, scientists think normal prion protein might help protect the brain from damage. Autoimmun Rev 2020;19:102597. Prion diseases include bovine spongiform . Prion diseases are incurable and always fatal. The paper goes into detail on the rise in the number of germinal centers in the draining lymph nodes, the exact location of all that B-cell selection and the corresponding antibody changes, which argues strongly that the antibody improvements mentioned in yesterday's post will occur after mRNA vaccination as well. CJD occurs worldwide and the estimated annual incidence in . A widely reposted 2021 Facebook post claiming that the mRNA vaccines against COVID-19 could cause prion diseases was based on a paper by J. Bart Classen. The reactogenicity of COVID-19 mRNA vaccine in individuals suffering from immune-mediated diseases and having therefore a pre-existent dysregulation of the immune response has not been investigated. Prion diseases can affect both humans and animals and are sometimes spread to humans by infected meat products. The most common form of prion disease that affects humans is Creutzfeldt-Jakob disease (CJD). Prion diseases are transmissible neurodegenerative diseases of humans and animals. Prion diseases comprise several conditions. The claim that COVID-19 vaccines can cause prion and other neurodegenerative diseases is FALSE, based on our research. Prion diseases are incurable and always fatal. Others [19] have reported a case of prion disease, Creutzfeldt-Jakob disease, initially occurring in a man with COVID-19. It is a neurodegenerative disorder with characteristic clinical and diagnostic features. Prions were first described as the method by which Mad Cow Disease causes brain degeneration due to misfolding proteins in the body. This should minimize the risks both of acute autoimmune reactions to inoculation and future chronic autoimmune pathology. Even the experts were startled by the remarkable success of the two first-of-their-kind messenger RNA vaccines developed by Moderna and Pfizer/BioNTech against COVID-19. None of the "fact checkers" can explain the cause of the excess rates. Gelatin is added to vaccines at the end of the manufacturing process. Gelatin is also used in the manufacture of vaccines. Prion diseases, or transmissible spongiform encephalopathies (TSE), are infectious neurodegenerative conditions that typically lead to cognitive and motor dysfunction , .With the exception of rare chronically presymptomatic carriers , prion diseases are progressive, fatal, and presently incurable.Prions propagate during the course of the disease and form aggregates containing PrP . COVID-19; Immune response; SARS-CoV-2; Type I interferon; mRNA vaccine. . vCJD (Variant Creutzfeldt-Jakob Disease) vCJD has a different clinical and pathologic characteristics from classic CJD. No one, to my knowledge . So let's look at the paper, which was published in an online journal, Microbiology & Infectious Diseases, and entitled " COVID-19 RNA Based Vaccines and the Risk of Prion Disease ". 1. At the moment, it can only be argued that prion diseases are fatal and incurable. The damage they do is explained in the following quotations. COVID-19; Immune response; SARS-CoV-2; Type I interferon; mRNA vaccine. The vaccine also demonstrated efficacy in preventing severe COVID-19. The vaccine delivers molecules of antigen-encoding mRNA into immune cells, which use the designed mRNA as a blueprint to build foreign protein that would normally be produced by a pathogen (such as a virus) or by a cancer cell. "There is no doubt the mRNA vaccines are causing prion diseases," Kirsch writes. Reviewing Some Possible Unintended Consequences of the mRNA Vaccines Against COVID-19," which was printed in the International Journal of Vaccine Theory, Practice and Research. Dr. Seneff believes the vaccine would exacerbate symptoms of those with Parkinson's. Those who claimed that mRNA would not impact DNA . Publication types Letter Comment MeSH terms . Vaccinated people will quickly transmit weaponized prions to the unvaccinated through bodily fluids, from saliva to sexual intercourse. Prion diseases, or transmissible spongiform encephalopathies (TSE), are infectious neurodegenerative conditions that typically lead to cognitive and motor dysfunction , .With the exception of rare chronically presymptomatic carriers , prion diseases are progressive, fatal, and presently incurable.Prions propagate during the course of the disease and form aggregates containing PrP . The prion agent consists of a misfolded protein, PrPSc (prion protein, scrapie form), of a glycosylphosphatidylinositol-anchored host protein, PrPC (PrP cellular form) of unknown function. It has to do with the extremely clever engineering that goes into mRNA vaccines. A prion is a type of protein that can trigger normal proteins in the brain to fold abnormally. None of the "fact checkers" can explain the cause of the excess rates. Reuters: Brian Appleby, professor at the School of Medicine, said there was no evidence mRNA vaccines cause neurodegenerative diseases, and that a journal article in question used the term prion disease "quite loosely" to refer to other protein misfolding disorders. This is especially concerning since the Pfizer vaccine is an mRNA vaccine, an untested type of vaccine which creates . . BMJ 2020;371:m4347. Clinically characterized by rapidly progressive dementia and accounting for 85% of human prion disease cases, sporadic Creutzfeldt-Jakob disease (sCJD) is the prevalent human prion disease. The study titled COVID-19 RNA Based Vaccines and the Risk of Prion Disease, was published in a journal, Microbiology & Infectious Diseases. Vaccines have treated infectious prions in mice, raising hopes of a cure for the deadly human version of "mad cow disease". Investigators identified no safety concerns and no evidence of vaccine-associated . In the current analysis a total of sixteen UG tandem repeats (ΨGΨG) were identified and additional UG (ΨG) rich sequences were identified. ABSTRACT Many have argued that SARS-CoV-2 spike protein and its mRNA sequence, found in all COVID-19 vaccines, are priongenic. Moreover, the genetic damage that such vaccines can cause would be irreversible and irreparable. . They are also not associated with neurodegenerative diseases or serious adverse effects other than rare cases . Prions are propagated in mammalian brains and not in cell culture used to make vaccines. Scientists say that two new vaccine therapies have finally produced. Concerns that the mRNA vaccines in particular, may cause neurodegenerative diseases have been widely shared on social media during the pandemic. Dr. Stephanie Seneff. 1012 14th Street, NW, Suite 205 People didn't have these diseases before the shot and suddenly they develop them after the shot. . Introduction. This point becomes important when we consider whether the COVID-19 vaccines might cause prion diseases. Anonymous Thu Mar 4 16:20:19 2021 No.12789718 [archived.moe] Or is it just a matter of not having any safety data on it at all (aside from the two months or whatever)? COVID vaccines that utilize mRNA such as the Pfizer-BioNTech and Moderna jabs use the coronavirus' spike protein to " . Publication types Letter Comment MeSH terms . Introduction. Indeed, experts in the mRNA discussion google group who first raised the hypothetical risks of LNP-encapsulated mRNA vaccines are still pro-vaccine, agreeing that SARS-CoV-2 or Covid-19 is the . An even more worrisome possibility is that these vaccines, both the mRNA vaccines and the DNA vector vaccines, may be a pathway to crippling disease sometime in the future. Ehrenfeld M, Tincani A, Andreoli L, et al. Prions is not actually a serious threat as it has never been observed in humans, right?